The Biostatistics of Aging (eBook)

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  • 88,247 Words
  • 272 Pages

A practical and clarifying approach to aging and aging-related diseases

Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population.

With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features:

  • Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values
  • A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations
  • The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology
  • An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles
  • The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software
  • Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases

The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.

A practical and clarifying approach to aging and aging-related diseases

Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population.

With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features:

  • Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values
  • A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations
  • The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology
  • An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles
  • The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software
  • Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases

The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.


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  • Released:
  • Categories: Education
  • Language: English
  • Publisher: Wiley
  • ISBN-10:
  • ISBN-13: 9781118645826
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by Bruce Levin, Gilberto Levy

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